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Niacinamide

Product Name    |    Niacinamide

Appearance    |    White powder

Grade    |    USP GRADE

Formula    |    C₆H₆N₂O

Type    |    Powder

CAS No    |    98-92-0

HS Code    |    29362920

Shelf life    |    Two years

Packing    |    25kg/DRUM, 16tons/20'FCL

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Description

What is Niacinamide?
Niacinamide, also known as vitamin B3, is a water-soluble vitamin that belongs to the B vitamins. It is an amide compound of niacin and is a white crystalline powder. As a medicinal ingredient, it has high safety. It is also a basic vitamin in clinical dermatology treatment. It can effectively treat skin problems such as photosensitive dermatitis and acne.
Niacinamide is the form of niacin in the human body. Niacin is also called vitamin B3. Niacin and nicotinamide together are called vitamin PP, and they are all B vitamins. Niacin is also called niacin, and nicotinamide is also called nicotinamide. Niacin and nicotinamide have similar physiological activities in the human body. Both can promote cell metabolism. As drugs or nutritional supplements, both can be used to prevent and treat roughness. But niacin has the effect of dilating blood vessels and lowering blood lipids, while nicotinamide has no such effect.

Specification
Name of product NICOTINAMIDE
Net. Weight 100g
N.of packages 25kg/carton
According to USP36
ANALYTICALITEMS SPECIFICATION ANALYTICAL RESULTS
Characteristics White crystalline powder Complies
ldentification Complies Complies
Melting range 128~131℃ 129~130℃
PH 5.5~7.5 7.2
Loss on drying ≤0.5% 0.10%
Residue on ignition ≤0.1% Complies
Heavy metals ≤0.003% ≤0.003%
Readily carbonizable ≤Matching Fluid A Complies
Nicotinic acid ≤100ppm <50ppm
Assay 98.5%~101.5% 99.60%


What does Niacinamide Do for Your Skin?
In 1974, Girish, Parsad, Mathur and others in the UK first discovered that combining nicotinamide and sunscreen into a cream system could absorb ultraviolet rays to prevent tanning and sunburn. Since then, many scientific research institutions have begun to pay attention to its application in the field of cosmetics. At first, nicotinamide was gradually promoted as a whitening ingredient. Later studies found that nicotinamide also has anti-aging, pore shrinking, and acne removal effects.

1. Anti-glycation, improve skin tone:
The whitening mechanism of nicotinamide includes three aspects: inhibiting the formation of melanin granules, inhibiting the transmission of melanin to keratinocytes, accelerating the transfer of melanin in keratinocytes to the stratum corneum, and promoting the shedding of the stratum corneum. At the same time, nicotinamide also has the effect of anti-glycation. During the aging process of skin, the contents of NADH (reduced coenzyme I) and NADPH (reduced coenzyme II) gradually decrease, and both control the entire process of intracellular synthesis and decomposition. High levels of NADPH exert a powerful antioxidant effect and prevent the spontaneous glycosylation reaction of proteins and sugars. The glycated proteins produced by the glycosylation reaction will be deposited in the dermis, causing the skin to appear yellowish-brown.

2. Strengthen skin barrier and fight aging:
Ceramide is an important component of the skin barrier. Niacinamide enhances the skin barrier function by increasing the ceramide content in the stratum corneum, reducing transepidermal water loss and improving skin resistance. In addition, nicotinamide can also promote the synthesis of proteins in the epidermis, so nicotinamide is also widely used in anti-aging skin care products. Long-term use of skin care products containing nicotinamide can improve skin texture and significantly reduce fine lines and wrinkles.

3. Balance oil secretion and shrink pores:
A considerable number of enlarged pores are caused by excessive secretion of oil in the skin. Niacinamide can significantly inhibit the production of sebum and make the secretion of sebum more appropriate and even. As oil secretion decreases, the pores, the channels through which the skin excretes sebum, will also slowly shrink, achieving the effect of shrinking pores.
As the precursor of NADH and NADPH, nicotinamide can play a role by regulating the balance of their levels in the body; nicotinamide can significantly increase the content of NADPH to exert an anti-glycation effect, thereby diluting the yellow color of protein glycation and brightening skin color.

4. Anti-inflammatory and acne removal:
Research shows that gel containing 4% nicotinamide is as effective in treating acne as 1% clindamycin gel. At present, the anti-inflammatory mechanism of nicotinamide is not clear. It may achieve anti-inflammatory effects by inhibiting the release of histamine from mast cells, inhibiting leukocyte chemotaxis and secretion of inflammatory mediators, blocking histamine receptors, and inhibiting the transfer of lymphocytes. effect.
In addition, because the amine group of nicotinamide can neutralize the free fatty acids in sebum, it can reduce the content of free fatty acids in pores, reduce the occurrence of skin inflammation, reduce the probability of acne, and maintain delicate and smooth skin.


What not to Mix with Niacinamide?
1. Niacinamide + high concentration acid = poisonous combination
Niacinamide is widely used in whitening products because niacinamide can reduce melanin and lighten spots and sun spots; fruit acids, salicylic acid, mandelic acid, etc. Different acids have different effects. Most high-concentration acids will generate heat when applied directly. There is redness and peeling, so it is recommended to go for medical aesthetic surgery. Acid will reduce the alkalinity of niacinamide, so the two cannot be used together.

2. Using fruit acid, salicylic acid, mandelic acid and other acids at the same time = bad face
Different acids have different effects, such as exfoliation, acne removal, whitening, etc. If multiple acids are mixed together, it will cause greater irritation to the skin, ranging from heat and redness to facial rot.

3. A alcohol + various acids = water and fire are incompatible
A-alcohol is widely used in anti-wrinkle products. If used together, acids will prevent A-alcohol from being converted more effectively.
Combinations of the above three categories may damage the skin at least, or ruin the face at worst, so please do not mix them together. However, if there is a toxic combination, there is a perfect match. It is the same formula above, but if you change the combination, it is a perfect CP, and the effect will be better when used together!


Clinical Applications of Nicotinamide?
Common clinical dosage forms of nicotinamide include nicotinamide injection and nicotinamide tablets. This product is a vitamin drug. Similar to niacin, it is a component of coenzyme I and coenzyme II. Participates in metabolic processes in the body and is necessary for lipid metabolism, oxidation of tissue respiration and glycogen decomposition. But it has no vasodilatory effect. In addition, this product can prevent and treat heart block, improve sinoatrial node function and resist tachyarrhythmia, and can significantly improve the heart rate slowdown and atrioventricular block caused by verapamil.
It is mainly used to prevent and treat arrhythmias associated with pellagra, coronary heart disease, viral myocarditis, rheumatic myocarditis and a small number of digitalis poisoning due to niacin deficiency. It has the effect of preventing and treating heart block.
In addition, nicotinamide can also stimulate beta cell regeneration, enhance beta cell resistance to damaging factors, and restore normal levels of coenzyme 1 in pancreatic islet cells, thereby slowing down the destruction of beta cells and promoting their regeneration.
Nicotinamide is also used to treat and prevent ocular neurodegenerative diseases, improve visual function of glaucoma patients, and prevent retinal nerve cell damage in patients.


Where to Buy Niacinamide in Bulk?
Niacinamide is a commonly used food additive and ingredient popular in many countries. As a professional Niacinamide supplier and manufacturer, Hangzhou Focus Corporation has nearly 10 years of experience in supplying and exporting Niacinamide  from China. You can safely choose to buy Niacinamide  from Hangzhou Focus Corporation. If you have any questions or concerns, please feel free to contact us and we will get back to you within 1 business day.

  1. If you have needs please contact us

Established in 2011, with 2 self-owned factories in 2015, Hangzhou Focus Corporation specializes in manufacture and trade of various kinds of food additives, including Niacinamide.We offer wholesale prices for bulk purchases, even for small quantities, and offer a free sample to potential customers.

  1. If you have needs please contact us
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FAQ

Q: Are you trading company or manufacturer ?

A: We are manufacturer.

Q: How long is your delivery time?

A: Generally it is 5-10 days if the goods are in stock. or it is 15-20 days if the goods are not in stock, it is according to quantity.

Q: Do you provide samples ? is it free or extra ?

A: Yes. We are pleased to provide the free sample while the freight cost may need you to undertake.but we will refund this freight cost when you place an order.

Q: What is your terms of payment ?

A: The payment method is flexible, we support various payment methods: TT/LC/CAD, all are acceptable, usually we use 30% TT IN ADVANCE,70% ONCE CARGOS READY.

If you have another question, pls feel free to contact us.

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